Bioorganic & medicinal chemistry letters

Synthesis and antitumor activity of s-tetrazine derivatives

WX Hu, GW Rao, YQ Sun

Index: Hu, Wei-Xiao; Rao, Guo-Wu; Sun, Ya-Quan Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1177 - 1181

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Citation Number: 95

Abstract

Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1, 6-dihydro, 1, 4- dihydro-, 1, 2-dihydro-and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10− 6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10− 6 μM have more than 50% ...