Helvetica Chimica Acta

Synthesis and Anti??HIV Activity of Triazolo??Fused 3′, 5′??Cyclic Nucleoside Analogues Derived from an Intramolecular Huisgen 1, 3??Dipolar Cycloaddition

J Sun, X Liu, H Li, R Duan, J Wu

Index: Sun, Jingbo; Liu, Xinyu; Li, Hongming; Duan, Ronghui; Wu, Jinchang Helvetica Chimica Acta, 2012 , vol. 95, # 5 p. 772 - 779

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Citation Number: 3

Abstract

Abstract Triazolo-fused 3′, 5′-cyclic nucleoside analogues were synthesized by an intramolecular 1, 3-dipolar cycloaddition of nucleoside-derived azido-alkynes in a regio-and stereospecific manner. The thymine nucleoside base in these target compounds was transformed successfully into the corresponding 5-methylcytosine component. The synthesized compounds were examined in a MAGI assay for exploring the anti-HIV activity ...

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