Reaction of different α-sulfonyl acetamides with methyl acrylate

MY Chang, ST Chen, NC Chang

Index: Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 25 p. 5075 - 5080

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Citation Number: 35

Abstract

The base-induced tandem-coupling/cyclization reactions of various α-sulfonyl acetamide derivatives A with methyl acrylate differentiated between two different pathways to form α- sulfonyl analogs of glutarimides B and 2-hydroxycyclohexenecarboxylic acid derivatives C in different ratios. The reaction of α-sulfonyl acetamide dianion with methyl acrylate depended on three factors: the stability of the dianion, concentration of methyl acrylate ...