The Journal of organic chemistry

Efficient Negishi Coupling Reactions of Aryl Chlorides Catalyzed by Binuclear and Mononuclear Nickel− N-Heterocyclic Carbene Complexes

Z Xi, Y Zhou, W Chen

Index: Xi, Zhenxing; Zhou, Yongbo; Chen, Wanzhi Journal of Organic Chemistry, 2008 , vol. 73, # 21 p. 8497 - 8501

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Citation Number: 85

Abstract

We describe the first nickel-N-heterocyclic carbene catalyzed Negishi cross-coupling reaction of a variety of unactivated aryl chlorides, heterocyclic chlorides, aryl dichlorides, and vinyl chloride. The mononuclear and binuclear nickel-NHC complexes supported by heteroarene-functionalized NHC ligands are found to be highly efficient for the coupling of unactivated aryl chlorides and organozinc reagents, leading to biaryls and terphenyls in ...

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