Improved and environmentally friendly large-scale preparation of cyclohexadienyl-, cycloheptadienyl sulfone and enantiopure epoxy cycloheptyl sulfones

T Park, E Torres, PL Fuchs

Index: Park, Taesik; Torres, Eduardo; Fuchs, Philip L. Synthesis, 2004 , # 11 p. 1895 - 1900

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Abstract

Abstract Kilogram-scale amounts of cycloheptadienyl phenylsulfone and cyclohexadienyl phenylsulfone were prepared by one operation in 5 stages with over 50% yield and requiring no purification. A practical and efficient method for the Jacobsen asymmetric epoxidation of 1, 3-cycloheptadienyl sulfone is described. The reported method is suitable for large-scale synthesis, does not use halogenated solvents nor does it require ...