Chemistry Letters

Peptide synthesis by using N-acylphosphoramidites

W Kawanobe, K Yamaguchi, S Nakahama…

Index: Kawanobe, Wataru; Yamaguchi, Kazuo; Nakahama, Seiichi; Yamazaki, Noboru Chemistry Letters, 1982 , p. 825 - 828

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Citation Number: 3

Abstract

New trivalent phosphorus compounds, N-acetyl-N-methylphosphoramidites were prepared readily in good yield by the reaction of phosphorous chlorides and N-methylacetamide. By using the phosphoramidites as condensing agents, Young's peptide and prolyl-leucyl- glycinamede (MSH-RIF) were synthesized without racemization in high yields under mild conditions.