2, 5-Dihydro-1, 2, 4-benzothiadiazepine 1, 1-dioxides. Synthesis and pharmacological evaluation

MP Fernández-Tomé, R Madronero…

Index: Fernandez-Tome; Madronero; Del Rio; Vega Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 887 - 890

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Citation Number: 5

Abstract

A new method of synthesis of 2, 5-dihydro-l, 2, 4benzothiadiazepine 1, l-dioxide derivatives via nitrilium salts is described. A number of the compounds were tested for acute toxicity and CNS activity in mice, and it was found that n-hexyl-substituted derivatives effectively