Synthetic communications

α-Chlorination of Ketones with Sodium Chlorite, Mn (acac) 3, and Alumina in Dichloromethane

S Yakabe, M Hirano, T Morimoto

Index: Yakabe, Shigetaka; Hirano, Masao; Morimoto, Takashi Synthetic Communications, 1998 , vol. 28, # 1 p. 131 - 138

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Citation Number: 15

Abstract

Abstract Chlorination of a variety of aliphatic, alicyclic, and aromatic ketones with a reagent combination of NaClO2 and Mn (acac) 3 catalyst can be readily performed in dichloromethane to afford α-chloroketones in good yield under mild and neutral conditions with the aid of chromatographic neutral alumina.

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