Chemistry Letters

Zinc (0)-copper (I) chloride promoted reaction of methyl dichlorofluoroacetate with carbonyl compounds. A new efficient method for the synthesis of methyl (Z)-. ALPHA …

T Ishihara, M Kuroboshi

Index: Ishihara, Takashi; Kuroboshi, Manabu Chemistry Letters, 1987 , p. 1145 - 1148

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Citation Number: 37

Abstract

Methyl dichlorofluoroacetate, easily prepared from methyl trichloroacetate and antimony (III) fluoride, underwent the reductive coupling–elimination reaction with carbonyl compounds in the presence of zinc (0), a catalytic amount of copper (I) chloride, acetic anhydride, and molecular sieves to give the corresponding (Z)-α-fluoro-α, β-unsaturated carboxylic acid methyl esters in high yields.