Enantioselective bioreduction of 2-fluoro-2-alken-1-ols mediated by Saccharomyces cerevisiae

F Luo, D Lu, Y Gong

Index: Luo, Fan; Lu, Dengfu; Gong, Yuefa Journal of Molecular Catalysis B: Enzymatic, 2011 , vol. 70, # 3-4 p. 101 - 107

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Citation Number: 12

Abstract

Biocatalytic reduction of 2-fluoro-2-alken-1-ols mediated by Saccharomyces cerevisiae underwent smoothly and yielded (S)-2-fluorinated alkanols with high enantioselectivities. The conversion rate was markedly depending on the configuration of alkene moiety of the substrate, the chain length of alkyl group at β position of CC bond, as well as the reaction conditions.