Application of a Flexible Synthesis of (5 R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase

JM McFadden, SM Medghalchi…

Index: Kunieda, Takehisa; Nagamatsu, Tomohisa; Higuchi, Tsunehiko; Hirobe, Masaaki Tetrahedron Letters, 1988 , vol. 29, # 18 p. 2203 - 2206

Full Text: HTML

Citation Number: 76

Abstract

... Volume: Page: ... Finally, a third subclass (16b, 29, 30) is also active against FAS (IC 50 = ≤20 μg/mL), is cytotoxic to cancer cells (IC 50 ... Acid hydrolysis of 17k−l provided acids 18a (98%) and 18b (89%, Scheme 8). Coupling reactions of 18 with EDC, or tris(2,3 ...

Related Articles:

Conversion of. beta.-amino esters to. beta.-lactams via tin (II) amides

[Wang; Roskamp Journal of the American Chemical Society, 1993 , vol. 115, # 21 p. 9417 - 9420]

Synthesis of β-amino arylketones through the addition of ArLi derivatives to β-aminoesters

[Lima, Paulo G.; Sequeira, Lucia C.; Costa, Paulo R.R. Tetrahedron Letters, 2001 , vol. 42, # 21 p. 3525 - 3527]

Convenient syntheses of cyclic carboxamides from. ALPHA.,. BETA.,. GAMMA.,. DELTA. and. EPSILON.-halocarboxamides under phase transfer conditions.

[Okawara, Tadashi; Matsuda, Takashi; Furukawa, Mitsuru Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1225 - 1233]

Convenient syntheses of cyclic carboxamides from. ALPHA.,. BETA.,. GAMMA.,. DELTA. and. EPSILON.-halocarboxamides under phase transfer conditions.

[Okawara, Tadashi; Matsuda, Takashi; Furukawa, Mitsuru Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1225 - 1233]

More Articles...