2-Aryl-2-hydroxyethylamine substituted 4-oxo-4, 7-dihydrothieno [2, 3-b] pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

ME Schnute, DJ Anderson, RJ Brideau, FL Ciske…

Index: Schnute, Mark E.; Anderson, David J.; Brideau, Roger J.; Ciske, Fred L.; Collier, Sarah A.; Cudahy, Michele M.; Eggen, MariJean; Genin, Michael J.; Hopkins, Todd A.; Judge, Thomas M.; Kim, Euibong J.; Knechtel, Mary L.; Nair, Sajiv K.; Nieman, James A.; Oien, Nancee L.; Scott, Allen; Tanis, Steven P.; Vaillancourt, Valerie A.; Wathen, Michael W.; Wieber, Janet L. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3349 - 3353

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Citation Number: 25

Abstract

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4, 7-dihydrothieno [2, 3-b] pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.