Tetrahedron

Facile S-alkyl thiocarbamate synthesis by a novel DBU-assisted carbonylation of amines with carbon monoxide and sulfur

T Mizuno, J Takahashi, A Ogawa

Index: Mizuno, Takumi; Takahashi, Junko; Ogawa, Akiya Tetrahedron, 2003 , vol. 59, # 8 p. 1327 - 1331

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Citation Number: 32

Abstract

A novel DBU-assisted carbonylation of amines with carbon monoxide and sulfur has been developed for the synthesis of S-alkyl thiocarbamates. In the presence of DBU (1, 8- diazabicyclo [5.4. 0] undec-7-ene), S-alkyl thiocarbamates are synthesized in excellent yields from amines, carbon monoxide, sulfur, and alkyl halides under mild conditions (1atm, 20° C). In the absence of DBU, however, no formation of S-alkyl thiocarbamate is ...

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