First Synthesis of γ, γ′-Diphosphonylketones and Their Reactivity in the Fischer Reaction

S Touil, H Zantour

Index: Touil, Soufiane; Zantour, Hedi Phosphorus, Sulfur and Silicon and Related Elements, 2002 , vol. 177, # 5 p. 1245 - 1254

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Citation Number: 17

Abstract

Two synthetic methods leading to the new n, n'-diphosphonylketones 2 and 2'are reported. The first method involves the base-catalyzed addition of diethylphosphite to diarylideneketones. The second one utilizes the reaction of triethylphosphite and ethoxydiphenylphosphine with g, g'-bis (dimethylamino) ketone hydrochlorides. On reaction with phenylhydrazine hydrochloride, compounds 2 and 2'give the corresponding 2-( ...