Organic process research & development

Development of a manufacturing route to 1-hydroxy-4-(3-pyridyl) butan-2-one using heck methodology

D Ainge, LM Vaz

Index: Ainge, Debra; Vaz, Luis-Manuel Organic Process Research and Development, 2002 , vol. 6, # 6 p. 811 - 813

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Citation Number: 8

Abstract

Many alternative synthetic routes were investigated. The second synthesis that was carried out at scale is detailed in Scheme 2 and relied on the enzymatic resolution of the racemic α-hydroxy ester 5. This route was successfully carried out by a contract manufacturer and provided 19 kg of 4. Initial calculations predicted this route could supply 3 at a suitable cost. However, the initial calculated cost was not realised, partly because of the cost associated with the ...