Aerobic Iron??Based Cross??Dehydrogenative Coupling Enables Efficient Diversity??Oriented Synthesis of Coumestrol??Based Selective Estrogen Receptor Modulators

UA Kshirsagar, R Parnes, H Goldshtein…

Index: Kshirsagar, Umesh A.; Parnes, Regev; Goldshtein, Hagit; Ofir, Rivka; Zarivach, Raz; Pappo, Doron Chemistry - A European Journal, 2013 , vol. 19, # 40 p. 13575 - 13583

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Citation Number: 26

Abstract

Abstract An iron-based cross-dehydrogenative coupling (CDC) approach was applied for the diversity-oriented synthesis of coumestrol-based selective estrogen receptor modulators (SERMs), representing the first application of CDC chemistry in natural product synthesis. The first stage of the two-step synthesis of coumestrol involved a modified aerobic oxidative cross-coupling between ethyl 2-(2, 4-dimethoxybenzoyl) acetate and 3-methoxyphenol, ...

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