Copper-Promoted overall transformation of 4-tert-butylphenol to its para-hydroxyquinonic derivative, 2-hydroxy-5-tert-butyl-1, 4-benzoquinone. Biomimetic studies on …

…, G Ponticelli, S Oliva, A Di Giulio, E Sanjust

Index: Rinaldi, Andrea C.; Ponticelli, Gustavo; Oliva, Stefania; Di Giulio, Antonio; Sanjust, Enrico Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 9 p. 989 - 992

Full Text: HTML

Citation Number: 5

Abstract

Topaquinone (TPQ) is a cofactor present at the active site of copper amine oxidases, derived from a Tyr residue inserted in the polypeptide chain through a copper-dependent but otherwise largely unknown mechanism. A simple model system was developed that permits to obtain the overall transformation of 4-tert-butylphenol, chosen as a model for Tyr, into a TPQ-like, para-hydroxyquinonic structure in the presence of Cu (II)-imidazole ...

Related Articles:

Copper (II)-mediated autoxidation of tert-butylresorcinols

[Ling, Ke-Qing; Lee, Younghee; Macikenas, Dainius; Protasiewicz, John D.; Sayre, Lawrence M. Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1358 - 1366]

Chemical simulation of biogenesis of the 2, 4, 5-trihydroxyphenylalanine quinone cofactor of copper amine oxidases: Mechanistic distinctions point toward a unique …

[Gierer,J.; Imsgard,F. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1977 , vol. 31, p. 537 - 545]

Über Orceinfarbstoffe, XXIII1). Die Autoxydation des 4.6??Di??tert.??butyl??resorcins

[Musso,H.; Maassen,D. Justus Liebigs Annalen der Chemie, 1965 , vol. 689, p. 93 - 108]

Über Orceinfarbstoffe, XXIII1). Die Autoxydation des 4.6??Di??tert.??butyl??resorcins

[Musso,H.; Maassen,D. Justus Liebigs Annalen der Chemie, 1965 , vol. 689, p. 93 - 108]

More Articles...