European journal of medicinal chemistry

Depsides as non-redox inhibitors of leukotriene B 4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid

SK KC, K Müller

Index: Kumar, Sunil; Mueller, Klaus European Journal of Medicinal Chemistry, 1999 , vol. 34, # 12 p. 1035 - 1042

Full Text: HTML

Citation Number: 1

Abstract

Aseries of barbatic and diffractaic acid analogues has been synthesized and evaluated as inhibitors of leukotriene B4 (LTB4) biosynthesis and as antiproliferative agents. The 4-O- demethyl barbatic and diffractaic acid derivatives were among the most active compounds in both assays. In particular, ethyl 4-O-demethylbarbatate was the most potent LTB4 biosynthesis inhibitor of this series, with an IC50 value in the submicromolar range. ...