Transition-metal-catalyzed domino reactions: efficient one-pot regiospecific synthesis of highly functionalized polysubstituted furans from electron-deficient alkynes …

H Cao, H Jiang, H Huang

Index: Cao, Hua; Jiang, Huanfeng; Huang, Huawen Synthesis, 2011 , # 7 p. 1019 - 1036

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Abstract

Abstract Based on the reactive behavior of different transition-metal catalysts, three methods for the synthesis of highly functionalized polysubstituted furan derivatives are presented:(i) copper (I) iodide catalyzed regiospecific synthesis of furan aldehydes/ketones from alkynols and diethyl but-2-ynedioate under atmospheric pressure;(ii) nano-Cu 2 O-catalyzed domino process for the regioselective synthesis of α-carbonylfurans from readily accessible ...