An S??Selective Lipase Was Created by Rational Redesign and the Enantioselectivity Increased with Temperature

…, M Takwa, A Hamberg, K Hult

Index: Magnusson, Anders O.; Takwa, Mohamad; Hamberg, Anders; Hult, Karl Angewandte Chemie - International Edition, 2005 , vol. 44, # 29 p. 4582 - 4585

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Citation Number: 119

Abstract

Lipases have characteristics that make them attractive tools for the synthesis of fine chemicals. They catalyze acyl-transfer reactions and are stable in organic solvents and at high temperatures. The possibility of modifying the performance of enzymes by biomolecular methods gives the opportunity to create tailor-made catalysts for each desired application. The high enantioselectivity of lipases toward secondary alcohols is a property often used ...