An inexpensive and highly stable ligand 1, 4-bis (2-hydroxy-3, 5-di-tert-butylbenzyl) piperazine for Mizoroki–Heck and room temperature Suzuki–Miyaura cross- …

S Mohanty, D Suresh, MS Balakrishna, JT Mague

Index: Mohanty, Sasmita; Suresh; Balakrishna, Maravanji S.; Mague, Joel. T. Tetrahedron, 2008 , vol. 64, # 1 p. 240 - 247

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Citation Number: 56

Abstract

A bulky, inexpensive and simple bidentate ligand 1, 4-bis (2-hydroxy-3, 5-di-tert-butylbenzyl) piperazine (1) has been synthesized and characterized. The palladium catalyst was formed by combination of 1 with [Cl2Pd (COD)] in a ratio of 1: 1, tested in the Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions. Coupling of a variety of aryl bromides with phenylboronic acid using methanol as solvent at room temperature, or at 60° C, gave ...