7, 8??Dioxochlorpromazine, synthesis and properties

…, JK Suzuki, JW Daly, AA Manian

Index: Zirnis; Suzuki; Daly; Manian Journal of Heterocyclic Chemistry, 1975 , vol. 12, # 2 p. 239 - 242

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Citation Number: 7

Abstract

Abstract 7, 8-Dihydroxychlorpromazine and 2-chloro-7, 8-dihydroxyphenothiazine were converted to the corresponding 7, 8-dioxo compounds by oxidation with tetrachloro-o- quinone. Spectral properties indicate that the 7, 8-dioxo compounds exist in zwitterionic forms reminiscent of aminochromes. The 7, 8-dioxochlorpromazine is proposed as a possible metabolite of chlorpromazine.