Concise strategy for the synthesis of eleven-membered and ansa-bridged thirteen-membered lactone macrolides by ring-closing metathesis reaction

KC Majumdar, B Chattopadhyay…

Index: Majumdar, Krishna C.; Chattopadhyay, Buddhadeb; Ansary, Inul Canadian Journal of Chemistry, 2009 , vol. 87, # 3 p. 472 - 477

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Citation Number: 7

Abstract

Recently, Singh et al. have reported 1 the isolation of two natural products, aspercyclides (Fig. 1, a and b), from the fungal metabolites and claimed that these natural products (a and b) possess several important biological activities. 2 The natural products aspercyclides consist of an eleven-membered lactone moiety that is flanked by differently substituted diaryl ether lactone. Subsequently, Furstner and Muller 3 achieved the total synthesis of “aspercyclide ...