Hypolipidemic substituted 1, 3-benzodioxole-2-carboxylates

…, GP Claxton, RA Parker, FP Palopoli…

Index: Grisar; Claxton; Parker; Palopoli; Kariya Journal of Medicinal Chemistry, 1974 , vol. 17, # 7 p. 721 - 725

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Citation Number: 6

Abstract

Ethyl 5-(4-fluoro-c~, cr-dimethylbenzyl)-1, 3-benzodioxole-2-carboxylate (1 1, RMI 14,676) was found to be a potent hypolipidemic agent, while ethyl 54 l-phenyl-l-cyclopentyl)-1, 3- benzodioxole-2-carboxylate (19, RMI 14,654), al-though less potent, was found to show only minimal hepatomegaly in young rats. The two compounds were selected from a series. of substituted 1, 3-benzodioxole-2-carboxylates and represent a novel type of cyclic analog ...