The preparation of 3??substituted 1, 2??benzisothiazole 1, 1??dioxides from lithiated intermediates or grignard reagents and methyl 2??(aminosulfonyl) benzoate

SP Dunn, LM Hajiaghamohseni, SB Lioi…

Index: Dunn, S. Patrick; Hajiaghamohseni, Laela M.; Lioi, Sara B.; Meierhoefer, Michelle A.; Walters, Matthew J.; Beam, Charles F. Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 2 p. 295 - 298

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Citation Number: 3

Abstract

Abstract A polylithiated β-ketoester, β-diketone, or β-ketoamide was condensed-cyclized with lithiated methyl 2-(aminosulfonyl) benzoate, to afford new 3-substituted 1, 2- benzisothiazole 1, 1-dioxides. Some Grignard or organolithium reagents were also condensed-cyclized with methyl 2-(aminosulfonyl) benzoate to give 3-substituted 1, 2- benzisothiazole 1, 1-dioxides.

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