Molecules

Synthesis and antitumor evaluation of novel derivatives of 6-amino-2-phenylbenzothiazoles

…, R Stojkovic, V Tralic-Kulenovic, G Karminski-Zamola

Index: Racane, Livio; Stojkovic, Ranko; Tralic-Kulenovic, Vesna; Karminski-Zamola, Grace Molecules, 2006 , vol. 11, # 5 p. 325 - 333

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Citation Number: 33

Abstract

Abstract: Novel derivatives of 6-amino-2-phenylbenzothiazole bearing different substituents (amino, dimethylamino or fluoro) on the phenyl ring were prepared as the corresponding hydrochloride salts. 6-Nitro-2-(substituted-phenyl) benzothiazoles (1-6) were synthesized by condensation reactions of substituted benzaldehydes with 2-amino-5-nitrothiophenol. Nitro derivatives were reduced to the amino derivatives with SnCl 2/HCl. Water soluble ...

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