Synthesis and antiviral activity evaluation of some aminoadamantane derivatives

N Kolocouris, GB Foscolos, A Kolocouris…

Index: Kolocouris, Nicolas; Foscolos, George B.; Kolocouris, Antonios; Marakos, Panayotis; Pouli, Nicole; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2896 - 2902

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Citation Number: 116

Abstract

The synthesis of some spiro [cyclopropane-l, 2'-adamantanl-2-amines and methanamines and some spiro [pyrrolidine-2, 2'-adamantanesl is described. The title compounds were evaluated against a wide range of viruses (influenza A, influenza B, parainfluenza 3, RSV, HSV-l,, TK-HSV-1, HSV-2, vaccinia, vesicular stomatitis, polio 1, Coxsackie B4, sindbis, semliki forest, Reo 1, HIV-1, and HIV-21, and some of them (compounds 6b, 6c, 9a, 16a, ...

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