Synthesis and anti-tumor activities of some new pyridines and pyrazolo [1, 5-a] pyrimidines

OM Ahmed, MA Mohamed, RR Ahmed…

Index: Ahmed, Osama M.; Mohamed, Mahmoud A.; Ahmed, Rasha R.; Ahmed, Sayed A. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3519 - 3523

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Citation Number: 63

Abstract

Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl) prop-2-en-1-one gives pyridin-2-one, pyridin-2 (1H)- thione, and pyrazolo [1, 5-a] pyrimidine derivatives. These derivatives showed potent anti- tumor cytotoxic activity in vitro using different human cancer cell lines.