A novel p-terphenyl derivative inducing cell-cycle arrest and apoptosis in MDA-MB-435 cells through topoisomerase inhibition

J Qiu, B Zhao, Y Shen, W Chen, Y Ma…

Index: Qiu, Jin; Zhao, Baobing; Shen, Yan; Chen, Wang; Ma, Yudao; Shen, Yuemao European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 192 - 202

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Citation Number: 9

Abstract

Abstract A novel series of p-terphenyl derivatives (1–4, 1a–4a) was successfully synthesized and their in vitro anticancer activities were evaluated. Compound 1, showing the best antiproliferative activity with IC 50< 1 μM against MDA-MB-435 cells, was further investigated. Compound 1 brought about a remarkable accumulation of MDA-MB-435 cells in G2/M phase prior to the induction of apoptosis. Further antitumor mechanism study ...