Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel …

…, B Cheval, M Martin, M Souchet, B Gout, A Bril

Index: Nadler, Guy; Faivre, Jean-Francois; Forest, Marie-Claire; Cheval, Brigitte; Martin, Michel; Souchet, Michel; Gout, Bernard; Bril, Antoine Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 11 p. 1993 - 2011

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Citation Number: 19

Abstract

Class III antiarrhythmic agents have been shown to prevent reentrant arrhythmias but also to be responsible for initiating arrhythmias characterised by afterdepolarizations and triggered activities. By combining potassium and calcium channel antagonistic actions, as with BRL- 32872 [1, 2](1), it might be possible to reduce the incidence of proarrhythmias albeit retaining antiarrhythmic efficacy. In the present study we synthesised and tested for their ...