A Highly Enantioselective Overman Rearrangement through Asymmetric Counteranion??Directed Palladium Catalysis

G Jiang, R Halder, Y Fang, B List

Index: Jiang, Gaoxi; Halder, Rajkumar; Fang, Yewen; List, Benjamin Angewandte Chemie - International Edition, 2011 , vol. 50, # 41 p. 9752 - 9755

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Citation Number: 62

Abstract

The Overman rearrangement is an important method for the construction of allylic amine derivatives from allylic imidates and has found widespread application in organic synthesis.[1] Since the first enantioselective version of this PdII-catalyzed aza-Claisen-type rearrangement appeared in 1997,[2] significant progress has been marked by the introduction of the oxazoline-based palladacycle catalysts COP-X [3] and FOPX [4]( ...

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