N-(heterocyclic alkyl) pyrido [2, 1-b] quinazoline-8-carboxamides as orally active antiallergy agents

…, P Levitan, J Lind, AF Welton, HJ Crowley…

Index: Tilley, Jefferson W.; Levitan, Paul; Lind, Joan; Welton, Ann F.; Crowley, Herman J.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 185 - 193

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Citation Number: 26

Abstract

7 a. 5-Hexyn-2. ol.(C, H&PdCI2, NEIl b. H2, Pd (C). c Oxalyi chloride, NEI,, DMSO,-6OOC. d. NaH3BCN, H, NCI. e CH& from the corresponding cyanomethyl ester 31. The amide 19 was prepared by a Ritter reaction between the nitrile 6 and the tertiary alcohol 7 (method E). The preparation of the new heterocyclic alkylamines required as starting materials for these condensations not previously described8-l1 is summarized in Schemes 11-V. Thus 3- ...