2-Phenyl-4-(aminomethyl) imidazoles as Potential Antipsychotic Agents. Synthesis and Dopamine D2 Receptor Binding

A Thurkauf, A Hutchison, J Peterson…

Index: Thurkauf, Andrew; Hutchison, Alan; Peterson, John; Cornfield, Linda; Meade, Robin; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2251 - 2255

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Citation Number: 22

Abstract

In order to examine the effects of various substitution patterns on the 2-phenyl ring, it became neccessary to hold the aminomethyl 'tail'constant. The N-methylbenzyl tail was chosen since the binding of its unsubstituted derivative was in the low micromolar range, and thus improvements in binding via changes in the 2-phenyl ring were judged to be easier to discern. The aromatic SAR of the 2-phenyl ring was carried out as follows (Table 1). ...