Green Chemistry

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

G Wu, W Yin, HC Shen, Y Huang

Index: Wu, Guiyong; Yin, Weiyu; Shen, Hong C.; Huang, Yong Green Chemistry, 2012 , vol. 14, # 3 p. 580 - 585

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Citation Number: 19

Abstract

To access useful heterocycles in medicinal chemistry such as pyridazinones, dihydropyrimidinones, and dihydropyrimidinthiones, a “green” mild and highly efficient one- pot triple cascade was developed involving a Claisen–decarboxylation, electrophilic reaction, and subsequent heterocyclization. In addition, indazoles and benzofurans could also be constructed via a double cascade. To develop the cascade process, a direct ...

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