(Acylaryloxy) acetic acid diuretics. 5.[(2-Alkyl-and 2, 2-disubstituted-1, 3-dioxo-5-indanyl) oxy] acetic acids

…, SJ DeSolms, GE Stokker, EJ Cragoe Jr

Index: Woltersdorf, O. W.; deSolms, S. J.; Stokker, G. E.; Cragoe, E. J. Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 840 - 845

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Citation Number: 5

Abstract

Investigation of the chemistry of the potent uricosuric diuretic indacrinone (MK-196) prompted the synthesis of a series of 3-OXO derivatives, Le., the indan-1, 3-diones. In general, both pharmacological parmameters (uricosuria and diuresis) were significantly less pronounced with the 1, 3-diones than with the parent 1-oxo compounds.