Reactivity of biologically important reduced pyridines V. Relative importance of electron versus proton loss in ferricyanide-mediated oxidation of dihydronicotinamides

…, JJ Kaminski, Z Gabanyi, K Czako, A Simay, N Bodor

Index: Brewster, Marcus E.; Kaminski, James J.; Gabanyi, Zoltan; Czako, Klara; Simay, Agnes; Bodor, Nicholas Tetrahedron, 1989 , vol. 45, # 14 p. 4395 - 4402

Full Text: HTML

Citation Number: 21

Abstract

Kinetics of ferricyanide-mediated oxidation of various 1-(4-substituted phenyl)-1, 4- dihydronicotinamides were studied assuming either a rate determining initial electron loss or a rate determining proton loss following a rapid pre-equilibrium step. Values obtained using both methods were similar. In addition, vertical ionization potentials generated using the AM1 molecular orbital approximation were found to be highly correlated with log ( ...