Total synthesis of iso [4]-levuglandin E2

G Subbanagounder, RG Salomon…

Index: Subbanagounder, Ganesamoorthy; Salomon, Robert G.; Murthi, Krishna K.; Brame, Cynthia; Jackson Roberts II Journal of Organic Chemistry, 1997 , vol. 62, # 22 p. 7658 - 7666

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Citation Number: 36

Abstract

Iso [4]-levuglandin E2 (iso [4]-LGE2, 5-acetyl-6-formyl-9-hydroxy-7 (E), 11 (Z)- heptadecadienoic acid) is a structural isomer of levuglandin E2 (8-acetyl-9-formyl-12- hydroxy-5 (Z), 10 (E)-heptadecadienoic acid) that we postulate to be generated during autoxidation of arachidonic acid or arachidonate esters. To facilitate detection and identification of iso [4]-LGE2 in biological samples, a succinct total synthesis was ...