3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin

WF Hoffman, AW Alberts, PS Anderson…

Index: Hoffman, W. F.; Alberts, A. W.; Anderson, P. S.; Chen, J. S.; Smith, R. L.; Willard, A. K. Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 849 - 852

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Citation Number: 254

Abstract

" Analytical results are within* 0.4% of the theoretical values. bSee Experimental Section for details of methods AC.'See Experimental Section for protocol. dFor estimation of relative inhibitory potencies, compactin was assigned a value of 100 and the IC,, value of the test compound was compared with that of compactin determined simultaneously.'C, H analysis was not obtained. The 360-, Hz NMR was in full agreement with the structure. IThe ...