Synlett

A Generic and Reproducible Route to Homo-and Heteroannular Bicyclic β-Diketones via Knochel-Type 1, 4-Conjugate Additions to α, β-Unsaturated Cycloalkenones

CL Hill, M McGrath, T Hunt, G Grogan

Index: Hill, Cheryl L.; McGrath, Matthew; Hunt; Grogan, Gideon Synlett, 2006 , # 2 p. 309 - 311

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Citation Number: 4

Abstract

Abstract A generic and reproducible method for the preparation of homo-and heteroannular bicyclic β-diketones is reported. The method employs the copper acetate mediated 1, 4- conjugate addition of organozinc derivatives of iodopropionate and iodobutanoate esters to α, β-unsaturated cycloalkenones, followed by intramolecular Dieckmann condensation.

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