3, 4, 5-Trifluorobenzeneboronic acid as an extremely active amidation catalyst

K Ishihara, S Ohara, H Yamamoto

Index: Ishihara, Kazuaki; Ohara, Suguru; Yamamoto, Hisashi Journal of Organic Chemistry, 1996 , vol. 61, # 13 p. 4196 - 4197

Full Text: HTML

Citation Number: 268

Abstract

There are several different routes to carboxamides. 1 In most of these reactions, a carboxylic acid is converted to a more reactive intermediate, eg, the acid chloride, which is then allowed to react with an amine. For practical reasons, it is preferable to form the reactive intermediate in situ. A carboxamide-forming reaction of the latter type has attracted our interest in the development of a reaction between carboxylic acids and primary or ...