Chemoenzymatic synthesis of α-halogeno-3-octanol and 4-or 5-nonanols. Application to the preparation of chiral epoxides

P Besse, T Sokoltchik, H Veschambre

Index: Besse, Pascale; Sokoltchik, Tania; Veschambre, Henri Tetrahedron Asymmetry, 1998 , vol. 9, # 24 p. 4441 - 4457

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Citation Number: 17

Abstract

A study of the microbiological reduction of different α-halogenoketones (4-chloro-3- octanone, 4-chloro-5-nonanone, 5-bromo-4-nonanone and 5-chloro-4-nonanone) with several strains of microorganism showed great difficulty in reducing ketone functions located in the middle of carbon chains. However, by choosing the appropriate microorganism, several enantiomerically pure diastereoisomers of the corresponding halohydrins have ...