Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway

PC Leow, P Bahety, CP Boon, CY Lee, KL Tan…

Index: Leow, Pay-Chin; Bahety, Priti; Boon, Choon Pei; Lee, Chong Yew; Tan, Kheng Lin; Yang, Tianming; Ee, Pui-Lai Rachel European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 67 - 80

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Citation Number: 17

Abstract

Abstract Osteosarcoma is a primary bone malignancy with aggressive metastatic potential and poor prognosis rates. In our earlier work we have investigated the therapeutic potential of curcumin as an anti-invasive agent in osteosarcoma by its ability to regulate the Wnt/β- catenin signaling pathway. However, the clinical use of curcumin is limited owing to its low potency and poor pharmacokinetic profile. In this study, an attempt was made to achieve ...