Tetrahedron

Efficient palladium-catalyzed amination of aryl chlorides using di (dicyclohexylamino) phenylphosphine as a PN 2 ligand

…, EJ Kim, IH Lee, GH Sung, JJ Kim, SG Lee, YJ Yoon

Index: Kim, Bo Ram; Cho, Su-Dong; Kim, Eun Jung; Lee, In-Hye; Sung, Gi Hyeon; Kim, Jeum-Jong; Lee, Sang-Gyeong; Yoon, Yong-Jin Tetrahedron, 2012 , vol. 68, # 1 p. 287 - 293

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Citation Number: 9

Abstract

The palladium-catalyzed amination of a variety of aryl chlorides has been accomplished by using di (dicyclohexylamino) phenylphosphine (1) as a bulky electron-rich monoaryl phosphine ligand. The optimized condition for the palladium-catalyzed amination of aryl chloride is the followings: aniline (3.0 mmol, 1.0 equiv), chlorobenzene (3.15 mmol, 1.05 equiv), ligand 1 (1 mol%, 0.03 mmol), KOtBu (4.5 mmol, 1.5 equiv), Pd2 (dba) 3 (1 mol%, ...