Platinum (II)-catalyzed intramolecular cyclization of alkynylbenzonitriles: synthesis of 1-alkoxyisoquinolines and isoquinolones

J Li, L Chen, E Chin, AS Lui, H Zecic

Index: Li, Jim; Chen, Lijing; Chin, Elbert; Lui, Alfred S.; Zecic, Hasim Tetrahedron Letters, 2010 , vol. 51, # 49 p. 6422 - 6425

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Citation Number: 9

Abstract

A facile synthesis of a series of 1-alkoxyisoquinolines and (2H)-isoquinolones by an intramolecular 6-endo-dig cyclization of ortho-alkynylbenzonitriles in the presence of a catalytic amount of hydrido (dimethylphosphinous acid-κP)[hydrogen bis (dimethylphosphinito-κP)] platinum (II) in various alcohols at 65–90° C is described for the first time.