Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-aminoethyl)-2 …

L Florvall, Y Kumar, AL Ask, I Fagervall…

Index: Florvall; Kumar; Ask; Fagervall; Renyi; Ross Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1406 - 1412

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Citation Number: 17

Abstract

Nine 5-(2-aminoethyl)-2, 3-dihydroindole derivatives were synthesized and tested as monoamine oxidase (MAO) inhibitors in vitro and in vivo. All compounds were found to be selective MAO-A inhibitors in vitro, the most active mes, 5-[l-i2-aminopropyl)]-2, 3-dihydro-4- methylindole acetate (3), 5-[l-(2-aminopropyl)]-4-chloro-2, 3-dihydroindole acetate (5), 5-[l-(2- aminopropyl)]-2, 3-dihydro-l-ethyl-4-methylindole tartrate (6), 5-[1-(2-aminopropy1)]-2, 3-di ...

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