Suzuki–Miyaura Cross-Coupling of Potassium Dioxolanylethyltrifluoroborate and Aryl/Heteroaryl Chlorides

…, D Oehlrich, F Rombouts, GA Molander

Index: Fleury-Bregeot, Nicolas; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A. Organic Letters, 2013 , vol. 15, # 7 p. 1536 - 1539

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Citation Number: 11

Abstract

A robust and efficient protocol for the introduction of the dioxolanylethyl moiety onto various aryl and heteroaryl halides has been developed, providing cross-coupling yields up to 93%. Copper-catalyzed borylation of 2-(2-bromoethyl)-1, 3-dioxolane with bis (pinacolato) diboron followed by treatment with potassium bifluoride provides the key organotrifluoroborate reagent.