Tetrahedron letters

Enantioposition-selective alkynylation of biaryl ditriflates by palladium-catalyzed asymmetric cross-coupling

T Kamikawa, Y Uozumi, T Hayashi

Index: Kamikawa, Takashi; Uozumi, Yasuhiro; Hayashi, Tamio Tetrahedron Letters, 1996 , vol. 37, # 18 p. 3161 - 3164

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Citation Number: 62

Abstract

Asymmetric cross-coupling of prochiral biaryl ditriflate, 1-[2, 6-bis [[(trifluoromethyl) sulfonyl] oxy] phenyl] naphthalene (1) or 1, 3-bis [[(trifluoromethyl) sulfonyl] oxy]-2-(biphenyl-2-yl) benzene (4) with triphenylsilylethynylmagnesium bromide in the presence of lithium bromide and 5 mol% of palladium catalyst, PdCl2 [(S)-Alaphos], proceeded with high enantioposition selectivity to give high yields of the corresponding axially chiral monoalkynylated b biaryls, ...