Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors

…, H Lucas, MJ Smit, ABJ Noach, TG Van Dinther…

Index: Rewinkel; Lucas; Smit; Noach; Van Dinther; Rood; Jenneboer; Van Boeckel Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2837 - 2842

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Citation Number: 20

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Replacement of the highly basic benzamidine moiety with moderate basic amino-bicycloaryl moieties in a series of thrombin inhibitors related to NAPAMP provided potent enzyme inhibition and significant improvements in membrane transport and oral bioavailability.