Tetrahedron

Rhodium or palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehydonitrile to access 3-aryl and 3-alkenyl phthalides

G Lv, G Huang, G Zhang, C Pan, F Chen, J Cheng

Index: Lv, Guanglei; Huang, Genping; Zhang, Guangyou; Pan, Changduo; Chen, Fan; Cheng, Jiang Tetrahedron, 2011 , vol. 67, # 26 p. 4879 - 4886

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Citation Number: 11

Abstract

Abstract A rhodium or palladium-catalyzed addition of boronic acids to phthalaldehydonitrile, followed by an intramolecular lactonization of cyano to access 3-substituted phthalides, is described. This procedure tolerates a series of functional groups, such as methoxy, fluoro, chloro, and vinyl groups. It is a novel procedure for the synthesis of 3-arylphthalides.

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