Chemical Communications

Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides

CH Xing, YX Liao, P He, QS Hu

Index: Xing, Chun-Hui; Liao, Yuan-Xi; He, Ping; Hu, Qiao-Sheng Chemical Communications, 2010 , vol. 46, # 17 p. 3010 - 3012

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Citation Number: 26

Abstract

Transition metal-catalyzed addition of arylboronic acids to 2-formylbenzoates afforded 3-substituted phthalides. By using SPINOL-based phosphites as ligands, a Rh(I)-catalyzed asymmetric version of such an addition reaction was achieved. ... Scheme 1 Mechanistic consideration for transition metal-catalyzed addition reactions of arylboronic acids with 2-formylbenzoates to access 3-substituted phthalides. ... Our study began with a test of the feasibility of the addition of ...

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